https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50220 Wed 28 Feb 2024 15:47:57 AEDT ]]> Towards a framework for better understanding of quiescent cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45157 Wed 26 Oct 2022 13:54:59 AEDT ]]> GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47696 Wed 25 Jan 2023 08:57:08 AEDT ]]> LncRNA IDH1-AS1 links the functions of c-Myc and HIF1a via IDH1 to regulate the Warburg effect https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47540 Wed 24 Jan 2024 15:22:27 AEDT ]]> BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30575 Wed 20 Mar 2019 12:05:15 AEDT ]]> Implication of unfolded protein response and autophagy in the treatment of BRAF inhibitor resistant melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28828 V600E mutation, is one of the key alterations in melanoma. Accordingly, two BRAF inhibitors (BRAFi), vemurafenib and dabrafenib are utilized to treat melanoma and resulted in an excellent clinical outcome. However, the clinical success is not long-lasting, and the BRAFi resistance and disease progression inevitably occurs in nearly all patients. Endoplasmic reticulum stress-induced unfolded protein response and autophagy have emerged as potential pro-survival mechanisms adopted by melanoma cells in response to BRAFi. In this review, we discuss the role of unfolded protein response and autophagy that are implicated in the development of BRAFi-resistant melanoma and the corresponding strategy aiming at overcoming the intractable clinical problem.]]> Wed 19 Jan 2022 15:18:22 AEDT ]]> c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37757 ARF in human and p19ARF in mouse) that binds to and inhibits mouse double minute 2 homolog (MDM2) leading to p53 activation, whereas p53 suppresses c-Myc through a combination of mechanisms involving transcriptional inactivation and microRNA-mediated repression. Nonetheless, the regulatory interactions between c-Myc and p53 are not retained by cancer cells as is evident from the often-imbalanced expression of c-Myc over wildtype p53. Although p53 repression in cancer cells is frequently associated with the loss of ARF, we disclose here an alternate mechanism whereby c-Myc inactivates p53 through the actions of the c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP). MILIP functions to promote p53 polyubiquitination and turnover by reducing p53 SUMOylation through suppressing tripartite-motif family-like 2 (TRIML2). MILIP upregulation is observed amongst diverse cancer types and is shown to support cell survival, division and tumourigenicity. Thus our results uncover an inhibitory axis targeting p53 through a pan-cancer expressed RNA accomplice that links c-Myc to suppression of p53.]]> Wed 17 Nov 2021 16:28:34 AEDT ]]> Cooperativity of HOXA5 and STAT3 is critical for HDAC8 inhibition-mediated transcriptional Activation of PD-L1 in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32982 Wed 17 Nov 2021 16:28:27 AEDT ]]> Histone deacetylases (HDACs) as mediators of resistance to apoptosis in melanoma and as targets for combination therapy with selective BRAF inhibitors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27649 Wed 17 May 2017 11:47:32 AEST ]]> Functional identification of a novel transcript variant of INPP4B in human colon and breast cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31508 Wed 15 Dec 2021 16:08:41 AEDT ]]> LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53-Defective Cancer Cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50273 Wed 12 Jul 2023 14:18:12 AEST ]]> Exploring neurotransmitters and their receptors for breast cancer prevention and treatment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52417 Wed 11 Oct 2023 11:58:33 AEDT ]]> Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20455 Wed 11 Apr 2018 16:49:10 AEST ]]> Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19023 V600E or MEK downregulated Noxa, whereas activation of MEK/ERK caused its upregulation. In addition, introduction of BRAFV600E increased Noxa expression in melanocytes. Upregulation of Noxa was due to a transcriptional increase mediated by cAMP responsive element binding protein, activation of which was also increased by MEK/ERK signaling in melanoma cells. Significantly, Noxa appeared necessary for constitutive activation of autophagy, albeit at low levels, by MEK/ERK in melanoma cells. Furthermore, it was required for autophagy activation that delayed apoptosis in melanoma cells undergoing nutrient deprivation. These results reveal that oncogenic activation of MEK/ERK drives Noxa expression to promote autophagy, and suggest that Noxa has an indirect anti-apoptosis role in melanoma cells under nutrient starvation conditions.]]> Wed 11 Apr 2018 16:41:25 AEST ]]> MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15166 V600E melanoma cells to B-RAF inhibitors. Experimental Design: B-RAFV600E melanoma cells were exposed to the B-RAF inhibitor PLX4720 for prolonged periods to select for cells resistant to apoptosis induced by the inhibitor. The resultant cells were analyzed for activation of extracellular signal regulated kinase (ERK), MAP/ERK kinase (MEK), and Akt, and related signals. Their roles in survival of the cells were also examined. Results: B-RAFV600E melanoma cells selected for resistant to PLX4720-induced apoptosis retained the V600E mutation in B-RAF, and proliferated steadily in the presence of the inhibitor, albeit with slow growth rate. These cells displayed high levels of ERK activation, that is, at least in part, independent of the conventional RAF/MEK/ERK pathway, as MEK activation was low and inhibition of MEK did not significantly block activation of ERK. In contrast, extracellular signals appeared involved. This was associated with elevated activation of the phosphoinositide 3-kinase (PI3k)/Akt pathway and could be inhibited by serum starvation and inhibition of PI3k/Akt. Inhibition of MEK did not impact on survival of these cells, whereas serum starvation, inhibition of PI3K/Akt, and inhibition of ERK1/2 reduced their viability. Conclusions: These results indicate that sensitivity to induction of apoptosis may be a major determinant of long-term responses of B-RAFV600E melanomas to specific inhibitors and suggest that rebound melanoma growth after initial treatment with the inhibitors may not be responsive to MEK inhibitors, but may be susceptible to inhibition of the PI3k/Akt pathway.]]> Wed 11 Apr 2018 16:15:39 AEST ]]> Evidence for upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15167 Wed 11 Apr 2018 16:01:18 AEST ]]> Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27772 Wed 11 Apr 2018 15:54:06 AEST ]]> Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14356 Wed 11 Apr 2018 15:41:30 AEST ]]> MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13811 Wed 11 Apr 2018 15:41:21 AEST ]]> 2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6913 Wed 11 Apr 2018 15:38:21 AEST ]]> TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18837 Wed 11 Apr 2018 15:08:53 AEST ]]> OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14361 Wed 11 Apr 2018 13:27:51 AEST ]]> Metabolic approaches to treatment of melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6915 Wed 11 Apr 2018 13:15:26 AEST ]]> RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28314 Wed 11 Apr 2018 12:40:55 AEST ]]> Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14352 Wed 11 Apr 2018 11:37:50 AEST ]]> Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9196 Wed 11 Apr 2018 10:54:31 AEST ]]> Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14871 Wed 11 Apr 2018 10:34:19 AEST ]]> Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5046 Wed 11 Apr 2018 10:25:08 AEST ]]> Treatment combinations targeting apoptosis to improve immunotherapy of melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6917 Wed 11 Apr 2018 09:56:34 AEST ]]> Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14383 Wed 11 Apr 2018 09:49:12 AEST ]]> Reactive oxygen species dictate the apoptotic response of melanoma cells to TH588 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28216 Wed 11 Apr 2018 09:38:40 AEST ]]> Low expression of microRNA-146b-5p and microRNA-320d predicts poor outcome of large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14869 Wed 11 Apr 2018 09:36:06 AEST ]]> INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22865 Wed 11 Apr 2018 09:31:09 AEST ]]> Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5430 Wed 11 Apr 2018 09:25:36 AEST ]]> BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32985 Wed 10 Nov 2021 15:04:52 AEDT ]]> Serum protein profiles of patients with lung cancer of different histological types https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28661 Wed 09 Mar 2022 16:03:03 AEDT ]]> Skp2-mediated stabilization of MTH1 promotes survival of melanoma cells upon oxidative stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32181 Wed 09 Mar 2022 15:58:36 AEDT ]]> Neurotrophin receptors TrkA, p75NTR, and sortilin are increased and targetable in thyroid cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36867 NTR, and the proneurotrophin receptor sortilin were analyzed with immunohistochemistry in a cohort of thyroid cancers (n = 128) and compared with adenomas and normal thyroid tissues (n = 62). TrkA was detected in 20% of thyroid cancers, compared with none of the benign samples (P = 0.0007). TrkA expression was independent of histologic subtypes but associated with lymph node metastasis (P = 0.0148), suggesting the involvement of TrkA in tumor invasiveness. Nerves in the tumor microenvironment were positive for TrkA. p75NTR was overexpressed in anaplastic thyroid cancers compared with papillary and follicular subtypes (P < 0.0001). Sortilin was overexpressed in thyroid cancers compared with benign thyroid tissues (P < 0.0001). Neurotrophin receptor expression was confirmed in a panel of thyroid cancer cell lines at the mRNA and protein levels. Functional investigations using the anaplastic thyroid cancer cell line CAL-62 found that siRNA against TrkA, p75NTR, and sortilin decreased cell survival and cell migration through decreased SRC and ERK activation. Together, these data reveal TrkA, p75NTR, and sortilin as potential therapeutic targets in thyroid cancer.]]> Wed 09 Feb 2022 15:52:42 AEDT ]]> Non-coding RNAs, metabolic stress and adaptive mechanisms in cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41023 Wed 08 Nov 2023 09:37:41 AEDT ]]> Cylindromatosis is required for survival of a subset of melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39074 Wed 04 May 2022 15:24:42 AEST ]]> Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28215 Wed 02 Mar 2022 14:25:48 AEDT ]]> A six-epithelial-mesenchymal transition gene signature may predict metastasis of triple-negative breast cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38374 Wed 01 Sep 2021 14:04:39 AEST ]]> PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54544 Tue 27 Feb 2024 20:39:49 AEDT ]]> Unveiling the prognostic implications of RPLP1 upregulation in osteosarcoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54459 Tue 27 Feb 2024 13:51:20 AEDT ]]> The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51136 Tue 22 Aug 2023 15:58:29 AEST ]]> A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25129 V600E/K mutation. In melanoma cells, loss of TRIM16 expression is a marker of cell migration and metastasis, while the BRAF inhibitor, vemurafenib, induces melanoma cell growth arrest in a TRIM16-dependent manner. Here we identify a novel small molecule compound which sensitized BRAF wild-type melanoma cells to vemurafenib. High throughput, cell-based, chemical library screening identified a compound (C012) which significantly reduced melanoma cell viability, with limited toxicity for normal human fibroblasts. When combined with the BRAFV600E/K inhibitor, vemurafenib, C012 synergistically increased vemurafenib potency in 5 BRAFWT and 4 out of 5 BRAFV600E human melanoma cell lines (Combination Index: CI < 1), and, dramatically reduced colony forming ability. In addition, this drug combination was significantly anti-tumorigenic in vivo in a melanoma xenograft mouse model. The combination of vemurafenib and C012 markedly increased expression of TRIM16 protein, and knockdown of TRIM16 significantly reduced the growth inhibitory effects of the vemurafenib and C012 combination. These findings suggest that the combination of C012 and vemurafenib may have therapeutic potential for the treatment of melanoma, and, that reactivation of TRIM16 may be an effective strategy for patients with this disease.]]> Thu 28 Oct 2021 12:37:19 AEDT ]]> A p53-responsive miRNA network promotes cancer cell quiescence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35745 chromosome 9 open reading frame 3 gene that was transcriptionally activated by p53. Similarly, the host gene of miRNA-455-3p, collagen alpha-1 (XXVII) chain, was also a p53 transcriptional target. Collectively, our results identify miRNA-27b-3p and miRNA-455-3p as important regulators of cancer cell quiescence in response to p53 and suggest that manipulating miRNA-27b-3p and miRNA-455-3p may constitute novel therapeutic avenues for improving outcomes of cancer treatment. Significance: Two novel p53-responsive microRNAs whose distinct mechanisms of action both stabilize p27 to promote cell quiescence and may serve as therapeutic avenues for improving outcomes of cancer treatment.]]> Thu 28 Oct 2021 12:36:09 AEDT ]]> Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45318 Thu 27 Oct 2022 13:56:46 AEDT ]]> The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45314 Thu 27 Oct 2022 13:56:29 AEDT ]]> Microbiome and Metabolic Features of Tissues and Feces Reveal Diagnostic Biomarkers For Colorectal Cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50515 Thu 27 Jul 2023 14:34:40 AEST ]]> LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37758 regenerating islet-derived (REG) gene family are important regulators of many cellular processes. Here we functionally characterise a non-protein coding product of the family, the long noncoding RNA (lncRNA) REG1CP that is transcribed from a DNA fragment at the family locus previously thought to be a pseudogene. REG1CP forms an RNA–DNA triplex with a homopurine stretch at the distal promoter of the REG3A gene, through which the DNA helicase FANCJ is tethered to the core promoter of REG3A where it unwinds double stranded DNA and facilitates a permissive state for glucocorticoid receptor α (GRα)-mediated REG3A transcription. As such, REG1CP promotes cancer cell proliferation and tumorigenicity and its upregulation is associated with poor outcome of patients. REG1CP is also transcriptionally inducible by GRα, indicative of feedforward regulation. These results reveal the function and regulation of REG1CP and suggest that REG1CP may constitute a target for cancer treatment.]]> Thu 27 Jan 2022 15:55:02 AEDT ]]> The emerging role of the microenvironment in endometrial cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36332 Thu 24 Mar 2022 11:36:03 AEDT ]]> The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33114 Thu 24 Mar 2022 11:29:56 AEDT ]]> CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48496 Thu 24 Aug 2023 13:57:43 AEST ]]> The double life of RIPK1 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50344 Thu 20 Jul 2023 14:26:55 AEST ]]> LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52635 Thu 19 Oct 2023 15:13:49 AEDT ]]> LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40825 Thu 18 Apr 2024 11:00:59 AEST ]]> BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32504 Thu 14 Apr 2022 10:59:36 AEST ]]> Stub1 maintains proteostasis of master transcription factors in embryonic stem cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53744 Thu 11 Jan 2024 12:15:03 AEDT ]]> TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52226 Thu 05 Oct 2023 10:31:40 AEDT ]]> LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39285 Thu 02 Jun 2022 15:26:26 AEST ]]> Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7006 Sat 24 Mar 2018 08:37:51 AEDT ]]> Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7007 Sat 24 Mar 2018 08:37:51 AEDT ]]> TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9621 Sat 24 Mar 2018 08:35:27 AEDT ]]> Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6918 Sat 24 Mar 2018 08:34:50 AEDT ]]> The emerging important role of microRNAs in the pathogenesis, diagnosis and treatment of human cancers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15221 Sat 24 Mar 2018 08:26:08 AEDT ]]> Antiproliferative effects of continued mitogen-activated protein kinase pathway inhibition following acquired resistance to BRAF and/or MEK inhibition in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14877 Sat 24 Mar 2018 08:22:24 AEDT ]]> Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10609 Sat 24 Mar 2018 08:13:49 AEDT ]]> Nucleotide excision repair gene expression after cisplatin treatment in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11525 Sat 24 Mar 2018 08:10:22 AEDT ]]> Contrasting effects of Nutlin-3 on TRAIL- and Docetaxel-induced Apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10447 Sat 24 Mar 2018 08:08:03 AEDT ]]> Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21386 Sat 24 Mar 2018 08:05:03 AEDT ]]> Obesity and melanoma: exploring molecular links https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18436 Sat 24 Mar 2018 07:59:47 AEDT ]]> Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20878 Sat 24 Mar 2018 07:57:56 AEDT ]]> The application of fungal beta-glucans for the treatment of colon cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18386 Sat 24 Mar 2018 07:52:36 AEDT ]]> The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20163 Sat 24 Mar 2018 07:51:41 AEDT ]]> Overcoming resistance to apoptosis in cancer therapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6686 Sat 24 Mar 2018 07:46:12 AEDT ]]> Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5319 Sat 24 Mar 2018 07:45:57 AEDT ]]> Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5341 Sat 24 Mar 2018 07:45:56 AEDT ]]> Involvement of endoplasmic reticulum stress in docetaxel-induced JNK-dependent apoptosis of human melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5394 Sat 24 Mar 2018 07:43:57 AEDT ]]> Melanoma cell sensitivity to docetaxal-induced apoptosis is determined by class III β-tubulin levels https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5398 Sat 24 Mar 2018 07:43:56 AEDT ]]> Involvement of vacuolar H⁺₋ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26890 Sat 24 Mar 2018 07:41:39 AEDT ]]> Guidelines for the use and interpretation of assays for monitoring autophagy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30350 Sat 24 Mar 2018 07:40:25 AEDT ]]> ER stress-induced autophagy in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28082 Sat 24 Mar 2018 07:39:48 AEDT ]]> Targeting apoptotic pathways in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25800 Sat 24 Mar 2018 07:34:44 AEDT ]]> RIP1 kinase is an oncogenic driver in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26954 Sat 24 Mar 2018 07:27:01 AEDT ]]> Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22856 PTEN and LKB1 - genes encoding phosphatase and tensin homolog and liver kinase B1, respectively - leads to the spontaneous development of cancer in mice. PTEN converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), whereas LKB1 activates the 5' adenosine monophosphate-activated protein kinase (AMPK). The kinase AKT and the kinase complex mTORC1 may play key roles in carcinogenesis and are components of signaling pathways that also contain PTEN and LKB1. We propose that via activation of AKT and mTORC1, the double knockout of PTEN and LKB1 contributes to distinct cell-specific aspects of tumor development and progression. Whereas mTORC1 promotes cancer initiation and progression through cell growth, survival, and proliferation, independent induction of the immune inhibitory molecule PD-L1 by activated AKT enables the tumors to evade immunosurveillance.]]> Sat 24 Mar 2018 07:16:02 AEDT ]]> The melanoma-associated antigen MAGE-D2 suppresses TRAIL receptor 2 and protects against TRAIL-induced apoptosis in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23422 Sat 24 Mar 2018 07:13:54 AEDT ]]> Guidelines for the use and interpretation of assays for monitoring autophagy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22060 Sat 24 Mar 2018 07:11:40 AEDT ]]> High nerve density in breast cancer is associated with poor patient outcome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48186 Sat 11 Mar 2023 12:23:00 AEDT ]]> Glycolytic Pfkp Acts as a Lin41 Protein Kinase to Promote Endodermal Differentiation of Embryonic Stem Cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50600 Mon 31 Jul 2023 11:20:02 AEST ]]> Evaluating nuclear translocation of surface receptors: recommendations arising from analysis of CD44 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39042 Mon 29 Jan 2024 17:54:16 AEDT ]]> Non-coding RNAs, guardians of the p53 galaxy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49571 Mon 22 May 2023 09:41:08 AEST ]]> SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40525 Mon 08 Aug 2022 15:05:19 AEST ]]> Expression of NGF/proNGF and Their Receptors TrkA, p75<sup>NTR</sup> and Sortilin in Melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51398 Mon 04 Sep 2023 14:57:50 AEST ]]> Inhibition of HSP90 by AUY922 preferentially kills mutant KRAS colon cancer cells by activating Bim through ER stress https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28221 Fri 16 Oct 2020 16:09:46 AEDT ]]> lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47238 Fri 16 Dec 2022 12:16:02 AEDT ]]> The emerging roles of rna m6a methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49407 Fri 12 May 2023 14:55:16 AEST ]]> LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54679 Fri 08 Mar 2024 11:46:03 AEDT ]]> RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36768 Fri 03 Jul 2020 14:41:43 AEST ]]> Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35545 Fri 03 Dec 2021 10:33:29 AEDT ]]>